| First Author | Alapin JM | Year | 2018 |
| Journal | Cell Rep | Volume | 23 |
| Issue | 7 | Pages | 2014-2025 |
| PubMed ID | 29768201 | Mgi Jnum | J:270997 |
| Mgi Id | MGI:6278365 | Doi | 10.1016/j.celrep.2018.04.042 |
| Citation | Alapin JM, et al. (2018) Activation of EphB2 Forward Signaling Enhances Memory Consolidation. Cell Rep 23(7):2014-2025 |
| abstractText | EphB2 is involved in enhancing synaptic transmission and gene expression. To explore the roles of EphB2 in memory formation and enhancement, we used a photoactivatable EphB2 (optoEphB2) to activate EphB2 forward signaling in pyramidal neurons in lateral amygdala (LA). Photoactivation of optoEphB2 during fear conditioning, but not minutes afterward, enhanced long-term, but not short-term, auditory fear conditioning. Photoactivation of optoEphB2 during fear conditioning led to activation of the cAMP/Ca(2+) responsive element binding (CREB) protein. Application of light to a kinase-dead optoEphB2 in LA did not lead to enhancement of long-term fear conditioning memory or to activation of CREB. Long-term, but not short-term, auditory fear conditioning memory was impaired in mice lacking EphB2 forward signaling (EphB2(lacZ/lacZ)). Activation of optoEphB2 in LA of EphB2(lacZ/lacZ) mice enhanced long-term fear conditioning memory. The present findings show that the level of EphB2 forward signaling activity during learning determines the strength of long-term memory consolidation. |
