| First Author | Logan SM | Year | 2013 |
| Journal | Neurosci Lett | Volume | 545 |
| Pages | 69-74 | PubMed ID | 23623938 |
| Mgi Jnum | J:201560 | Mgi Id | MGI:5514328 |
| Doi | 10.1016/j.neulet.2013.04.025 | Citation | Logan SM, et al. (2013) Ephrin-B2 expression in the proprioceptive sensory system. Neurosci Lett 545:69-74 |
| abstractText | Recent studies have shown that ephrin-B2 on sensory afferent fibers from the dorsal root ganglia (DRG) controls transmission of pain sensation to the spinal cord. We examined ephrin-B2 expression in mouse DRG and spinal cord using an ephrin-B2/ss-galactosidase chimeric allele. We found that ephrin-B2 is expressed exclusively in proprioceptive neurons and fibers in neonates, while expression in lamina III and IV of the adult spinal cord was observed in addition to that in the deeper laminae. We confirmed that ephrin-B2 protein causes co-clustering of EphB2 and glutamate receptors in spinal cord neurons. Our data are consistent with a role for ephrin-B2 in transmission of positional information to the CNS, and thus suggest a role in synaptic plasticity of spinal cord locomotor circuits that are known to be sensitive to proprioceptive sensory input after spinal cord injury. |
