| First Author | Chen M | Year | 2023 |
| Journal | Int J Biol Sci | Volume | 19 |
| Issue | 16 | Pages | 5160-5173 |
| PubMed ID | 37928265 | Mgi Jnum | J:342425 |
| Mgi Id | MGI:7547789 | Doi | 10.7150/ijbs.86207 |
| Citation | Chen M, et al. (2023) Targeting Aquaporin-3 Attenuates Skin Inflammation in Rosacea. Int J Biol Sci 19(16):5160-5173 |
| abstractText | Rosacea is a common inflammatory skin disorder mediated by the dysregulation of both keratinocytes and T cells. Here, we report that aquaporin 3 (AQP3), a channel protein that mediates the transport of water/glycerol, was highly expressed in the epidermis and CD4(+) T cells of both rosacea patients and experimental mice. Specifically, AQP3 deletion blocked the development of rosacea-like skin inflammation in model mice with LL37-induced rosacea-like disease. We also present mechanistic evidence showing that AQP3 was essential to the activation of NF-kappaB signaling and subsequent production of disease-characteristic chemokines in keratinocytes. Moreover, we show that AQP3 was upregulated during T cell differentiation and promotes helper T (Th) 17 differentiation possibly via the activation of STAT3 signaling. Our findings reveal that AQP3-mediated activation of NF-kappaB in keratinocytes and activation of STAT3 in CD4(+) T cells acted synergistically and contributed to the inflammation in rosacea. |
