| First Author | El Yacoubi M | Year | 2006 |
| Journal | Behav Brain Res | Volume | 171 |
| Issue | 2 | Pages | 279-85 |
| PubMed ID | 16712972 | Mgi Jnum | J:110634 |
| Mgi Id | MGI:3640750 | Doi | 10.1016/j.bbr.2006.04.003 |
| Citation | El Yacoubi M, et al. (2006) Behavioral characterization of CD26 deficient mice in animal tests of anxiety and antidepressant-like activity. Behav Brain Res 171(2):279-85 |
| abstractText | CD26 exhibits a dipeptidylpeptidase-IV function (DPPIV) which regulates neuropeptide activity by N-terminal processing. Because abnormal plasma DPPIV was associated in mammals with behavioral changes, we examined the behavior of CD26-/- mice resulting from targeted inactivation of the gene. These animals had a decreased immobility in the forced swim and tail suspension tests, indicating a reduced depression-like behavior. We addressed some factors that could affect these results. No major differences between mutants and controls were observed in the black/white box test that investigates anxiety. In the hole-board apparatus that explores both curiosity and anxiety, CD26-/- mice of both genders made significantly more head dips than controls. In a motor activity test, mutants displayed higher horizontal and vertical activities i.e. increased novelty-induced behavioral activation. We conclude that DPPIV inactivation in mice broadly leads to an antidepressant-like and hyperactive phenotype. |
