| First Author | Lutter M | Year | 2008 |
| Journal | Nat Neurosci | Volume | 11 |
| Issue | 7 | Pages | 752-3 |
| PubMed ID | 18552842 | Mgi Jnum | J:139356 |
| Mgi Id | MGI:3807808 | Doi | 10.1038/nn.2139 |
| Citation | Lutter M, et al. (2008) The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. Nat Neurosci 11(7):752-3 |
| abstractText | We found that increasing ghrelin levels, through subcutaneous injections or calorie restriction, produced anxiolytic- and antidepressant-like responses in the elevated plus maze and forced swim test. Moreover, chronic social defeat stress, a rodent model of depression, persistently increased ghrelin levels, whereas growth hormone secretagogue receptor (Ghsr) null mice showed increased deleterious effects of chronic defeat. Together, these findings demonstrate a previously unknown function for ghrelin in defending against depressive-like symptoms of chronic stress. |
