| First Author | Kakizaki M | Year | 2019 |
| Journal | iScience | Volume | 20 |
| Pages | 1-13 | PubMed ID | 31546102 |
| Mgi Jnum | J:278619 | Mgi Id | MGI:6359712 |
| Doi | 10.1016/j.isci.2019.09.003 | Citation | Kakizaki M, et al. (2019) Differential roles of each orexin receptor signaling in obesity. iScience |
| abstractText | Orexins are hypothalamic neuropeptides which regulate feeding, energy expenditure and sleep. Although orexin-deficient mice are susceptible to obesity, little is known about the roles of the orexin receptors in long-term energy metabolism. Here, we performed the metabolic characterization of orexin receptor-deficient mice. Ox1r-deficient mice were resistant to diet-induced obesity and their food intake was similar between chow and high-fat food. Ox2r-deficient mice exhibited less energy expenditure than wild-type mice when fed a high-fat diet. Neither Ox1r-deficient nor Ox2r-deficient mice showed body weight gain similar to orexin-deficient mice. Although the presence of a running wheel suppressed diet-induced obesity in wild-type mice, the effect was weaker in orexin neuron-ablated mice. Finally, we did not detect abnormalities in brown adipose tissues of orexin-deficient mice. Thus, each orexin receptor signaling has a unique role in energy metabolism, and orexin neurons are involved in the interactive effect of diet and exercise on body weight gain. |
