| Primary Identifier | MGI:2151935 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(APPV717F)109Ili |
| Strain of Origin | Not Specified | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Overexpression of a human APP (hAPP) minigene encoding the APP717V to F mutation associated with familial Alzheimer's Disease. The construct contained APP introns 6 - 8, allowing alternative splicing of exons 7 and 8. The transgene utilizes a platelet-derived growth factor promoter (PDGF-b) and the three major splicing variants of hAPP mRNA were expressed in transgenic mice. As determined by RNAse protection, line 109 expressed ~ 18-fold more APP than previously described neuron-specific enolase (NSE)-promoter-driven APP transgenes. |
