| First Author | Winsky-Sommerer R | Year | 2004 |
| Journal | Brain Res | Volume | 1023 |
| Issue | 1 | Pages | 157-62 |
| PubMed ID | 15364032 | Mgi Jnum | J:92565 |
| Mgi Id | MGI:3053505 | Doi | 10.1016/j.brainres.2004.04.082 |
| Citation | Winsky-Sommerer R, et al. (2004) Overexpression of the human beta-amyloid precursor protein downregulates cortistatin mRNA in PDAPP mice. Brain Res 1023(1):157-62 |
| abstractText | We measured preprocortistatin mRNA expression in young and aged transgenic (Tg) mice overexpressing the human beta-amyloid precursor protein (hbetaAPP) under the platelet-derived growth factor-beta promoter. Our findings suggest that the significant increase in hippocampal cortistatin mRNA expression during normal aging is significantly attenuated in Tg mice at an age known to exhibit beta-amyloid protein (Abeta) deposition. These deficits in cortistatin expression may play a role in the deficits in hippocampal-dependent spatial learning and sleep/wake states previously demonstrated in aged Tg mice. |
