| First Author | Dodart JC | Year | 1999 |
| Journal | Neurosci Lett | Volume | 277 |
| Issue | 1 | Pages | 49-52 |
| PubMed ID | 10643895 | Mgi Jnum | J:60044 |
| Mgi Id | MGI:1352566 | Doi | 10.1016/s0304-3940(99)00847-2 |
| Citation | Dodart JC, et al. (1999) Early regional cerebral glucose hypometabolism in transgenic mice overexpressing the V717F beta-amyloid precursor protein. Neurosci Lett 277(1):49-52 |
| abstractText | In the present study, we examined whether the relative levels of regional brain [14C]2-deoxyglucose (2-DG) uptake are altered in a transgenic mouse model of Alzheimer's disease which overexpresses a mutated form of the human beta-amyloid precursor protein (mutation V717F). We show that the relative levels of 2-DG uptake are significantly reduced in the septum, thalamus, dentate gyrus and parietal cortex of 3-month-old transgenic mice as compared with wild-type littermates. In 10-month-old transgenic mice, these alterations also extend to the CA3 hippocampal region, the cingulate, retrosplenial, occipital and temporal cortices, suggesting an age-dependent decrease in the regional 2-DG uptake. These results suggest that expression of a mutated APP gene induces an early regional cerebral hypometabolism independently of amyloid deposition per se. |
