| First Author | De Meyer SF | Year | 2010 |
| Journal | Arterioscler Thromb Vasc Biol | Volume | 30 |
| Issue | 10 | Pages | 1949-51 |
| PubMed ID | 20616311 | Mgi Jnum | J:182111 |
| Mgi Id | MGI:5314723 | Doi | 10.1161/ATVBAHA.110.208918 |
| Citation | De Meyer SF, et al. (2010) Binding of von Willebrand factor to collagen and glycoprotein Ibalpha, but not to glycoprotein IIb/IIIa, contributes to ischemic stroke in mice--brief report. Arterioscler Thromb Vasc Biol 30(10):1949-51 |
| abstractText | OBJECTIVE: To unravel crucial von Willebrand factor (VWF) interactions that are detrimental in stroke development. METHODS AND RESULTS: VWF(-/-) mice received gene transfer to express mutants of VWF defective either in binding to fibrillar collagen, glycoprotein (GP)Ibalpha or GPIIb/IIIa, and underwent 60 minutes of transient middle cerebral artery occlusion. In VWF(-/-) mice reconstituted with VWF mutants defective in binding to collagen or GPIbalpha, protection against stroke was sustained, whereas VWF lacking the GPIIb/IIIa binding site restored full susceptibility similar to normal VWF. CONCLUSIONS: VWF-collagen and VWF-GPIbalpha (but not VWF-GPIIb/IIIa) interactions are instrumental in thrombus formation after transient middle cerebral artery occlusion, and their inhibition could be a promising target for stroke treatment. |
