| First Author | Fernandez-Salguero P | Year | 1995 |
| Journal | Science | Volume | 268 |
| Issue | 5211 | Pages | 722-6 |
| PubMed ID | 7732381 | Mgi Jnum | J:25048 |
| Mgi Id | MGI:72762 | Doi | 10.1126/science.7732381 |
| Citation | Fernandez-Salguero P, et al. (1995) Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor [see comments]. Science 268(5211):722-6 |
| abstractText | The aryl hydrocarbon (Ah) receptor (AHR) mediates many carcinogenic and teratogenic effects of environmentally toxic chemicals such as dioxin. An AHR-deficient (Ahr-/-) mouse line was constructed by homologous recombination in embryonic stem cells. Almost half of the mice died shortly after birth, whereas survivors reached maturity and were fertile. The Ahr-/- mice showed decreased accumulation of lymphocytes in the spleen and lymph nodes, but not in the thymus. The livers of Ahr-/- mice were reduced in size by 50 percent and showed bile duct fibrosis Ahr-/- mice were also nonresponsive with regard to dioxin-mediated induction of genes encoding enzymes that catalyze the metabolism of foreign compounds. Thus, the AHR plays an important role in the development of the liver and the immune system. |
