| First Author | Clipperton-Allen AE | Year | 2015 |
| Journal | Genes Brain Behav | Volume | 14 |
| Issue | 2 | Pages | 145-57 |
| PubMed ID | 25561290 | Mgi Jnum | J:235927 |
| Mgi Id | MGI:5803952 | Doi | 10.1111/gbb.12192 |
| Citation | Clipperton-Allen AE, et al. (2015) Decreased aggression and increased repetitive behavior in Pten haploinsufficient mice. Genes Brain Behav 14(2):145-57 |
| abstractText | Aggression is an aspect of social behavior that can be elevated in some individuals with autism spectrum disorder (ASD) and a concern for peers and caregivers. Mutations in Phosphatase and tensin homolog (PTEN), one of several ASD risk factors encoding negative regulators of the PI3K-Akt-mTOR pathway, have been reported in individuals with ASD and comorbid macrocephaly. We previously showed that a mouse model of Pten germline haploinsufficiency (Pten(+/-) ) has selective deficits, primarily in social behavior, along with broad overgrowth of the brain. Here, we further examine the social behavior of Pten(+/-) male mice in the resident-intruder test of aggression, using a comprehensive behavioral analysis to obtain an overall picture of the agonistic, non-agonistic and non-social behavior patterns of Pten(+/-) mice during a free interaction with a novel conspecific. Pten(+/-) male mice were involved in less aggression than their wild-type littermates. Pten(+/-) mice also performed less social investigation, including anogenital investigation and approaching and/or attending to the intruder, which is consistent with our previous finding of decreased sociability in the social approach test. In contrast to these decreases in social behaviors, Pten(+/-) mice showed increased digging. In summary, we report decreased aggression and increased repetitive behavior in Pten(+/-) mice, thus extending our characterization of this model of an ASD risk factor that features brain overgrowth and social deficits. |
