| First Author | DeBosch BJ | Year | 2016 |
| Journal | Sci Signal | Volume | 9 |
| Issue | 416 | Pages | ra21 |
| PubMed ID | 26905426 | Mgi Jnum | J:260287 |
| Mgi Id | MGI:6140621 | Doi | 10.1126/scisignal.aac5472 |
| Citation | DeBosch BJ, et al. (2016) Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis. Sci Signal 9(416):ra21 |
| abstractText | Trehalose is a naturally occurring disaccharide that has gained attention for its ability to induce cellular autophagy and mitigate diseases related to pathological protein aggregation. Despite decades of ubiquitous use as a nutraceutical, preservative, and humectant, its mechanism of action remains elusive. We showed that trehalose inhibited members of the SLC2A (also known as GLUT) family of glucose transporters. Trehalose-mediated inhibition of glucose transport induced AMPK (adenosine 5''-monophosphate-activated protein kinase)-dependent autophagy and regression of hepatic steatosis in vivo and a reduction in the accumulation of lipid droplets in primary murine hepatocyte cultures. Our data indicated that trehalose triggers beneficial cellular autophagy by inhibiting glucose transport. |
