| First Author | Sweeney E | Year | 2008 |
| Journal | Dev Dyn | Volume | 237 |
| Issue | 10 | Pages | 2693-704 |
| PubMed ID | 18629872 | Mgi Jnum | J:139808 |
| Mgi Id | MGI:3810196 | Doi | 10.1002/dvdy.21594 |
| Citation | Sweeney E, et al. (2008) Altered endochondral ossification in collagen X mouse models leads to impaired immune responses. Dev Dyn 237(10):2693-704 |
| abstractText | Disruption of collagen X function in hypertrophic cartilage undergoing endochondral ossification was previously linked to altered hematopoiesis in collagen X transgenic (Tg) and null (KO) mice (Jacenko et al., [2002] Am J Pathol 160:2019-2034). Mice displayed altered growth plates, diminished trabecular bone, and marrow hypoplasia with an aberrant lymphocyte profile throughout life. This study identifies altered B220(+), CD4(+), and CD8(+) lymphocyte numbers, as well as CD4(+)/fox3P(+) T regulatory cells in the collagen X mice. Additionally, diminished in vitro splenocyte responses to mitogens and an inability of mice to survive a challenge with Toxoplasma gondii, confirm impaired immune responses. In concert, ELISA and protein arrays identify aberrant levels of inflammatory, chemo-attractant, and matrix binding cytokines in collagen X mouse sera. These data link the disruption of collagen X function in the chondro-osseous junction to an altered hematopoietic stem cell niche in the marrow, resulting in impaired immune function. Developmental Dynamics 237:2693-2704, 2008. (c) 2008 Wiley-Liss, Inc. |
