| First Author | Guillemot F | Year | 1995 |
| Journal | Nat Genet | Volume | 9 |
| Issue | 3 | Pages | 235-42 |
| PubMed ID | 7773285 | Mgi Jnum | J:23260 |
| Mgi Id | MGI:71027 | Doi | 10.1038/ng0395-235 |
| Citation | Guillemot F, et al. (1995) Genomic imprinting of Mash2, a mouse gene required for trophoblast development. Nat Genet 9(3):235-42 |
| abstractText | The mouse gene Mash2 encodes a transcription factor required for development of trophoblast progenitors. Mash2-homozygous mutant embryos die at 10 days postcoitum from placental failure. Here we show that Mash2 is genomically imprinted. First, Mash2+/- embryos inheriting a wild-type allele from their father die at the same stage as -/- embryos, with a similar placental phenotype. Second, the Mash2 paternal allele is initially expressed by groups of trophoblast cells at 6.5 and 7.5 days post-coitum, but appears almost completely repressed by 8.5 days post-coitum. Finally, we have genetically and physically mapped Mash2 to the distal region of chromosome 7, within a cluster of imprinted genes, including insulin-2, insulin-like growth factor-2 and H19. |
