| First Author | Trokovic N | Year | 2003 |
| Journal | Genes Dev | Volume | 17 |
| Issue | 1 | Pages | 141-53 |
| PubMed ID | 12514106 | Mgi Jnum | J:81179 |
| Mgi Id | MGI:2448210 | Doi | 10.1101/gad.250703 |
| Citation | Trokovic N, et al. (2003) Fgfr1 regulates patterning of the pharyngeal region. Genes Dev 17(1):141-53 |
| abstractText | Development of the pharyngeal region depends on the interaction and integration of different cell populations, including surface ectoderm, foregut endoderm, paraxial mesoderm, and neural crest. Mice homozygous for a hypomorphic allele of Fgfr1 have craniofacial defects, some of which appeared to result from a failure in the early development of the second branchial arch. A stream of neural crest cells was found to originate from the rhombomere 4 region and migrate toward the second branchial arch in the mutants. Neural crest cells mostly failed to enter the second arch, however, but accumulated in a region proximal to it. Both rescue of the hypomorphic Fgfr1 allele and inactivation of a conditional Fgfr1 allele specifically in neural crest cells indicated that Fgfr1 regulates the entry of neural crest cells into the second branchial arch non-cell-autonomously. Gene expression in the pharyngeal ectoderm overlying the developing second branchial arch was affected in the hypomorphic Fgfr1 mutants at a stage prior to neural crest entry. Our results indicate that Fgfr1 patterns the pharyngeal region to create a permissive environment for neural crest cell migration. |
