| First Author | Kharbanda S | Year | 1998 |
| Journal | Oncogene | Volume | 16 |
| Issue | 14 | Pages | 1773-7 |
| PubMed ID | 9583675 | Mgi Jnum | J:124453 |
| Mgi Id | MGI:3721728 | Doi | 10.1038/sj.onc.1201934 |
| Citation | Kharbanda S, et al. (1998) Functional role for the c-Abl tyrosine kinase in meiosis I. Oncogene 16(14):1773-7 |
| abstractText | The c-Abl tyrosine kinase is activated by ionizing radiation and certain other DNA-damaging agents. The DNA-dependent protein kinase (DNA-PK) and the ataxia telangiectasia mutated (ATM) gene product, effectors in the DNA damage response, contribute to the induction of c-Abl activity. The present study demonstrates that c-Abl is expressed in mouse and rat testes, and predominantly in pachytene spermatocytes of meiosis I. The results also demonstrate that c-Abl interacts directly with meiotic chromosomes. In concert with a requirement for c-Abl at the pachytene stage, we show that, in contrast to wild-type mice, testes from Abl-/- mice exhibit defects in spermatogenesis. These findings provide the first demonstration that c-Abl plays a functional role in meiosis. |
