| First Author | Berrettini WH | Year | 1994 |
| Journal | Nat Genet | Volume | 7 |
| Issue | 1 | Pages | 54-8 |
| PubMed ID | 8075641 | Mgi Jnum | J:17972 |
| Mgi Id | MGI:65995 | Doi | 10.1038/ng0594-54 |
| Citation | Berrettini WH, et al. (1994) Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains [see comments]. Nat Genet 7(1):54-8 |
| abstractText | Quantitative trait loci mapping was used to identify the chromosomal location of genes which contribute to oral morphine preference (in a two-bottle choice paradigm) of C57BL/6J mice, compared to DBA/2J mice. An F2 intercross of these two strains (606 mice) was phenotyped for morphine preference and those mice demonstrating extreme values for morphine consumption (the highest and lowest 7.7%) were genotyped for 157 murine microsatellite polymorphisms. Maximum likelihood methods revealed three loci on murine chromosomes 1, 6 and 10 which are responsible for nearly 85% of the genetic variance observed between the two parental strains. |
