| First Author | Fernández MA | Year | 2006 |
| Journal | Science | Volume | 313 |
| Issue | 5793 | Pages | 1628-32 |
| PubMed ID | 16973879 | Mgi Jnum | J:112452 |
| Mgi Id | MGI:3656350 | Doi | 10.1126/science.1130773 |
| Citation | Fernandez MA, et al. (2006) Caveolin-1 is essential for liver regeneration. Science 313(5793):1628-32 |
| abstractText | Liver regeneration is an orchestrated cellular response that coordinates cell activation, lipid metabolism, and cell division. We found that caveolin-1 gene-disrupted mice (cav1-/- mice) exhibited impaired liver regeneration and low survival after a partial hepatectomy. Hepatocytes showed dramatically reduced lipid droplet accumulation and did not advance through the cell division cycle. Treatment of cav1-/- mice with glucose (which is a predominant energy substrate when compared to lipids) drastically increased survival and reestablished progression of the cell cycle. Thus, caveolin-1 plays a crucial role in the mechanisms that coordinate lipid metabolism with the proliferative response occurring in the liver after cellular injury. |
