Primary Identifier | MGI:2154553 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Lama3 |
Transmission | Germline | Strain of Origin | 129/Sv |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A neomycin resistance cassette replaced a genomic fragment containing exon A3. This exon encodes sequences common to both isoforms of the protein. Removal of this exon is predicted to cause a frameshift mutation and result in premature termination of the protein. Immunohistochemistry analysis on skin derived from homozygous mice confirmed that the protein was not detectable. |