| First Author | Kumar S | Year | 2015 |
| Journal | Cell Rep | Volume | 12 |
| Issue | 8 | Pages | 1325-38 |
| PubMed ID | 26279573 | Mgi Jnum | J:313613 |
| Mgi Id | MGI:6791206 | Doi | 10.1016/j.celrep.2015.07.034 |
| Citation | Kumar S, et al. (2015) Sox9 Activation Highlights a Cellular Pathway of Renal Repair in the Acutely Injured Mammalian Kidney. Cell Rep 12(8):1325-38 |
| abstractText | After acute kidney injury (AKI), surviving cells within the nephron proliferate and repair. We identify Sox9 as an acute epithelial stress response in renal regeneration. Translational profiling after AKI revealed a rapid upregulation of Sox9 within proximal tubule (PT) cells, the nephron cell type most vulnerable to AKI. Descendants of Sox9(+) cells generate the bulk of the nephron during development and regenerate functional PT epithelium after AKI-induced reactivation of Sox9 after renal injury. After restoration of renal function post-AKI, persistent Sox9 expression highlights regions of unresolved damage within injured nephrons. Inactivation of Sox9 in PT cells pre-injury indicates that Sox9 is required for the normal course of post-AKI recovery. These findings link Sox9 to cell intrinsic mechanisms regulating development and repair of the mammalian nephron. |
