| First Author | Yabaji SM | Year | 2023 |
| Journal | Sci Adv | Volume | 9 |
| Issue | 39 | Pages | eadh4119 |
| PubMed ID | 37756395 | Mgi Jnum | J:349672 |
| Mgi Id | MGI:7538434 | Doi | 10.1126/sciadv.adh4119 |
| Citation | Yabaji SM, et al. (2023) Cell state transition analysis identifies interventions that improve control of Mycobacterium tuberculosis infection by susceptible macrophages. Sci Adv 9(39):eadh4119 |
| abstractText | Understanding cell state transitions and purposefully controlling them to improve therapies is a longstanding challenge in biological research and medicine. Here, we identify a transcriptional signature that distinguishes activated macrophages from the tuberculosis (TB) susceptible and resistant mice. We then apply the cSTAR (cell state transition assessment and regulation) approach to data from screening-by-RNA sequencing to identify chemical perturbations that shift the transcriptional state of tumor necrosis factor (TNF)-activated TB-susceptible macrophages toward that of TB-resistant cells, i.e., prevents their aberrant activation without suppressing beneficial TNF responses. Last, we demonstrate that the compounds identified with this approach enhance the resistance of the TB-susceptible mouse macrophages to virulent Mycobacterium tuberculosis. |
