| First Author | Vempati UD | Year | 2009 |
| Journal | J Biol Chem | Volume | 284 |
| Issue | 7 | Pages | 4383-91 |
| PubMed ID | 19075019 | Mgi Jnum | J:147780 |
| Mgi Id | MGI:3842078 | Doi | 10.1074/jbc.M805972200 |
| Citation | Vempati UD, et al. (2009) Lack of cytochrome c in mouse fibroblasts disrupts assembly/stability of respiratory complexes I and IV. J Biol Chem 284(7):4383-91 |
| abstractText | Cytochrome c (cyt c) is a heme-containing protein that participates in electron transport in the respiratory chain and as a signaling molecule in the apoptotic cascade. Here we addressed the effect of removing mammalian cyt c on the integrity of the respiratory complexes in mammalian cells. Mitochondria from cyt c knockout mouse cells lacked fully assembled complexes I and IV and had reduced levels of complex III. A redox-deficient mutant of cyt c was unable to rescue the levels of complexes I and IV. We found that cyt c is associated with both complex IV and respiratory supercomplexes, providing a potential mechanism for the requirement for cyt c in the assembly/stability of complex IV. |
