| First Author | Wandstrat AE | Year | 2004 |
| Journal | Immunity | Volume | 21 |
| Issue | 6 | Pages | 769-80 |
| PubMed ID | 15589166 | Mgi Jnum | J:94686 |
| Mgi Id | MGI:3513699 | Doi | 10.1016/j.immuni.2004.10.009 |
| Citation | Wandstrat AE, et al. (2004) Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus. Immunity 21(6):769-80 |
| abstractText | Susceptibility to autoimmunity in B6.Sle1b mice is associated with extensive polymorphisms between two divergent haplotypes of the SLAM/CD2 family of genes. The B6.Sle1b-derived SLAM/CD2 family haplotype is found in many other laboratory mouse strains but only causes autoimmunity in the context of the C57Bl/6 (B6) genome. Phenotypic analyses have revealed variations in the structure and expression of several members of the SLAM/CD2 family in T and B lymphocytes from B6.Sle1b mice. T lymphocytes from B6.Sle1b mice have modified signaling responses to stimulation at 4-6 weeks of age. While autoimmunity may be mediated by a combination of genes in the SLAM/CD2 family cluster, the strongest candidate is Ly108, a specific isoform of which is constitutively upregulated in B6.Sle1b lymphocytes. |
