| Primary Identifier | MGI:2154928 | Allele Type | QTL |
| Gene | Abhr2 | Inheritance Mode | Not Specified |
| Strain of Origin | A/J | Is Recombinase | false |
| Is Wild Type | false |
| description | Two-way ANOVA analysis detected interaction between Abrh1 and Abhr2. Hc (hemolytic complement) at 23.5 cM maps to the Abhr2 QTL interval and was identified as a candidate gene in a microarray analysis of lung mRNA from A/J, C3H/HeJ, and (A/J x C3H/HeJ)F1 x A/J backcross animals. The A/J allele of Hc has a 2 bp deletion resulting in deficient Hc mRNA and protein production, and is associated with susceptibility to allergen-induced bronchial hyperresponsiveness. |
