| First Author | Renard V | Year | 1995 |
| Journal | Proc Natl Acad Sci U S A | Volume | 92 |
| Issue | 16 | Pages | 7545-9 |
| PubMed ID | 7638228 | Mgi Jnum | J:28186 |
| Mgi Id | MGI:75811 | Doi | 10.1073/pnas.92.16.7545 |
| Citation | Renard V, et al. (1995) Normal development and function of natural killer cells in CD3 epsilon delta 5/delta 5 mutant mice. Proc Natl Acad Sci U S A 92(16):7545-9 |
| abstractText | The CD3 epsilon polypeptide contributes to the cell surface display as well as to the signal transduction properties of the T-cell antigen receptor complex. Intriguingly, the distribution of CD3 epsilon is not restricted to T cells, since activated mouse, human, and avian natural killer (NK) cells do express intracytoplasmic CD3 epsilon polypeptides. CD3 epsilon is also present in the cytoplasm of fetal thymic T/NK bipotential progenitor cells, suggesting that it constitutes a component of the NK differentiation program. We report here that the genetic disruption of CD3 epsilon exon 5 alters neither NK cell development nor in vitro and in vivo NK functions, although it profoundly blocked T-cell development. These results support the notion that CD3 epsilon is dispensable for mouse NK cell ontogeny and function and further suggest that the common NK/T-cell progenitor cell utilizes CD3 epsilon as a mandatory component only when differentiating toward the T-cell lineage. |
