| First Author | Perruzza L | Year | 2017 |
| Journal | Cell Rep | Volume | 18 |
| Issue | 11 | Pages | 2566-2575 |
| PubMed ID | 28297661 | Mgi Jnum | J:256195 |
| Mgi Id | MGI:6103318 | Doi | 10.1016/j.celrep.2017.02.061 |
| Citation | Perruzza L, et al. (2017) T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP. Cell Rep 18(11):2566-2575 |
| abstractText | The ATP-gated ionotropic P2X7 receptor regulates T follicular helper (Tfh) cell abundance in the Peyer''s patches (PPs) of the small intestine; deletion of P2rx7, encoding for P2X7, in Tfh cells results in enhanced IgA secretion and binding to commensal bacteria. Here, we show that Tfh cell activity is important for generating a diverse bacterial community in the gut and that sensing of microbiota-derived extracellular ATP via P2X7 promotes the generation of a proficient gut ecosystem for metabolic homeostasis. The results of this study indicate that Tfh cells play a role in host-microbiota mutualism beyond protecting the intestinal mucosa by induction of affinity-matured IgA and suggest that extracellular ATP constitutes an inter-kingdom signaling molecule important for selecting a beneficial microbial community for the host via P2X7-mediated regulation of B cell help. |
