| First Author | Almeida AR | Year | 2006 |
| Journal | Int Immunol | Volume | 18 |
| Issue | 11 | Pages | 1607-13 |
| PubMed ID | 16987936 | Mgi Jnum | J:114962 |
| Mgi Id | MGI:3690482 | Doi | 10.1093/intimm/dxl093 |
| Citation | Almeida AR, et al. (2006) Competition controls the rate of transition between the peripheral pools of CD4+CD25- and CD4+CD25+ T cells. Int Immunol 18(11):1607-13 |
| abstractText | Recent reports have hinted that it is possible to regenerate CD4+CD25+ regulatory T cells (Treg) from CD4+CD25- cells, a phenomenon termed conversion. We evaluated the relative contribution of this process to the Treg pool by transferring purified populations of CD4+ T cells into T cell-deficient mice. We report that conversion of CD25- cells into the CD4+CD25+Treg pool is minor if other bona fide CD25+ Tregs are present. Moreover, in the same hosts, the loss of CD25 expression by a population of Tregs also decreases in the presence of co-injected CD4+CD25- cells. Thus, the rate of exchange between CD25- and CD25+ T-cell populations is determined by the presence or absence of T-cell competitors. Our results attest for the role of competition in the contribution of different T-cell subsets for the regeneration of the peripheral CD4+ T-cell pool during lymphopenia. |
