| First Author | Poitrasson-Rivière M | Year | 2008 |
| Journal | J Immunol | Volume | 180 |
| Issue | 11 | Pages | 7294-304 |
| PubMed ID | 18490729 | Mgi Jnum | J:136309 |
| Mgi Id | MGI:3795978 | Doi | 10.4049/jimmunol.180.11.7294 |
| Citation | Poitrasson-Riviere M, et al. (2008) Regulatory CD4+ T cells are crucial for preventing CD8+ T cell-mediated autoimmunity. J Immunol 180(11):7294-304 |
| abstractText | In vivo studies have shown that regulatory CD4(+) T cells regulate conventional CD4(+) T cell responses to self- and environmental Ags. However, it remains unclear whether regulatory CD4(+) T cells control CD8(+) T cell responses to self, directly, or indirectly by decreasing available CD4(+) T cell help. We have developed an experimental mouse model in which suppressive and helper T cells cannot mediate their functions. The mouse chimeras generated were not viable and rapidly developed multiple organ autoimmunity. These features were correlated with strong CD8(+) T cell activation and accumulation in both lymphoid and nonlymphoid organs. In vivo Ab treatment and secondary transfer experiments demonstrated that regulatory CD4(+) T cells play an important direct role in the prevention of peripheral CD8(+) T cell-mediated autoimmunity. |
