| First Author | Degroot A | Year | 2006 |
| Journal | Eur J Pharmacol | Volume | 531 |
| Issue | 1-3 | Pages | 183-6 |
| PubMed ID | 16455072 | Mgi Jnum | J:112784 |
| Mgi Id | MGI:3663555 | Doi | 10.1016/j.ejphar.2005.12.036 |
| Citation | Degroot A, et al. (2006) Genetic deletion of muscarinic M4 receptors is anxiolytic in the shock-probe burying model. Eur J Pharmacol 531(1-3):183-6 |
| abstractText | We used muscarinic M2 and M4 receptor knockout (KO) mice to further explore the role of the cholinergic system in anxiety. Using the shock-probe burying model we were able to both assess anxiety and cognition. In this paradigm, an anxiolytic response is reflected by decreased burying behavior. In addition, retention latency depicts long-term memory performance. Whereas muscarinic M2 receptor KO mice did not differ behaviorally from wild-type mice, muscarinic M4 receptor KO mice showed increased anxiolysis, but normal long-term memory compared to wild-type mice. Therefore, muscarinic M4 receptors are of particular significance in anxiety modulation that seems dissociated from changes in long-term memory. |
