| First Author | Rise ML | Year | 1991 |
| Journal | Science | Volume | 253 |
| Issue | 5020 | Pages | 669-73 |
| PubMed ID | 1871601 | Mgi Jnum | J:11381 |
| Mgi Id | MGI:59817 | Doi | 10.1126/science.1871601 |
| Citation | Rise ML, et al. (1991) Genes for epilepsy mapped in the mouse. Science 253(5020):669-73 |
| abstractText | The neurological mutant mouse strain E1 is a model for complex partial seizures in humans. The inheritance of epileptic seizures with seven conventional chromosomal markers and over 60 endogenous proviral markers was studied by means of back-crosses of E1 with two seizure-resistant strains, DBA/2J and ABP/LeJ. The major gene responsible for this epileptic phenotype (El-1) was localized to a region distal with respect to the centromere on chromosome 9. At least one other gene, El-2, linked to proviral markers on chromosome 2, also influences the seizure phenotype. In addition, a potential modifier of seizures was detected in the DBA/2J background. The location of El-1 on distal chromosome 9 may allow identification of an epilepsy candidate gene in humans on the basis of conserved synteny with human chromosome 3. |
