| First Author | Tankersley CG | Year | 1998 |
| Journal | J Appl Physiol (1985) | Volume | 85 |
| Issue | 1 | Pages | 360-5 |
| PubMed ID | 9655796 | Mgi Jnum | J:49024 |
| Mgi Id | MGI:1276327 | Doi | 10.1152/jappl.1998.85.1.360 |
| Citation | Tankersley CG, et al. (1998) Differential inspiratory timing is genetically linked to mouse chromosome 3. J Appl Physiol 85(1):360-5 |
| abstractText | Genetic control of differential inspiratory timing (TI) at baseline has been previously demonstrated among inbred mouse strains. The inheritance pattern for TI between C3H/HeJ (C3; 188 +/- 3 ms) and C57BL/6J (B6; 111 +/- 2 ms) progenitors was consistent with a two-gene model. By using the strain distribution pattern for recombinant inbred strains derived from C3 and B6 progenitors, 100% concordance was established between TI phenotypes and DNA markers on mouse chromosome 3. This genotype-phenotype hypothesis was tested by typing 52 B6C3F(2) (F-2) progeny by using simple sequence repeat DNA markers (n = 21) polymorphic between C3 and B6 strains on mouse chromosome 3. Linkage analysis compared marker genotypes to baseline ventilatory phenotypes by computing log-likelihood values. A putative quantitative trait locus located in proximity to D3Mit119 was significantly associated with baseline TI phenotypes. At the peak (log-likelihood = 3.3), the putative quantitative trait locus determined 25% of the phenotypic variance in TI among F-2 progeny. In conclusion, this genetic model of ventilatory characteristics demonstrated an important linkage between differential baseline TI and a candidate genomic region on mouse chromosome 3. |
