| First Author | Kim JH | Year | 2001 |
| Journal | Genomics | Volume | 74 |
| Issue | 3 | Pages | 273-86 |
| PubMed ID | 11414755 | Mgi Jnum | J:70227 |
| Mgi Id | MGI:2136594 | Doi | 10.1006/geno.2001.6569 |
| Citation | Kim JH, et al. (2001) Genetic analysis of a new mouse model for non-insulin-dependent diabetes. Genomics 74(3):273-86 |
| abstractText | The TallyHo (TH) mouse strain is a newly established model for non-insulin-dependent diabetes mellitus(NIDDM). TH mice show obesity, hyperinsulinemia, hyperlipidemia, and male-limited hyperglycemia. A genetic dissection of the diabetes syndrome has been carried out using male backcross 1 progeny obtained from crosses between (C57BL/6J x TH)F1 and TH mice or (CAST/Ei x TH)F1 and TH mice. A genome-wide scan reveals three quantitative trait loci (QTLs), Tanidd1-3 (TH-associated NIDDM) linked to hyperglycemia. The major QTL (common in both crosses), Tanidd1, maps to chromosome (Chr) 19. Additionally, gene-gene interactions contributing to hyperglycemia have been observed between Tanidd1 and a locus on Chr 18 as well as between Tanidd2 and a locus on Chr 16. The overt hyperglycemia in TH mice is, therefore, likely due to a mutation in a major diabetes susceptibility locus on Chr 19, which interacts with additional genes to lead to an observable phenotype. Copyright 2001 Academic Press. |
