| First Author | Cui JG | Year | 2004 |
| Journal | Neuroreport | Volume | 15 |
| Issue | 13 | Pages | 2025-8 |
| PubMed ID | 15486475 | Mgi Jnum | J:103695 |
| Mgi Id | MGI:3610626 | Doi | 10.1097/00001756-200409150-00006 |
| Citation | Cui JG, et al. (2004) Potential roles for presenilin-1 in oxygen sensing and in glial-specific gene expression. Neuroreport 15(13):2025-8 |
| abstractText | The integral membrane glycoprotein presenilin-1 (PS1), in concert with beta-secretase and beta amyloid precursor protein (betaAPP), orchestrate cleavage of betaAPP into amyloidogenic Abeta peptides. To gain further insight into PS1 function, we undertook a gene expression profiling study that interrogated the expression of 12,000 genes in the forebrain of PS1-hypomorphic mice that exhibit highly attenuated PS1 activity. Using stringent RNA screening, DNA array and Northern assay, we report significant down-regulation in the expression of betaAPP and hypoxia inducible factor-1 alpha (HIF-1alpha), and a marked up-regulation in the expression of glial-specific markers that include S100beta protein, glycerol phosphate dehydrogenase, and glial fibrillary acidic protein. These data suggest potential roles for PS1 in the cellular response to hypoxia and glial-specific gene expression. |
