| First Author | Morel L | Year | 1994 |
| Journal | Immunity | Volume | 1 |
| Issue | 3 | Pages | 219-29 |
| PubMed ID | 7889410 | Mgi Jnum | J:25006 |
| Mgi Id | MGI:72721 | Doi | 10.1016/1074-7613(94)90100-7 |
| Citation | Morel L, et al. (1994) Polygenic control of susceptibility to murine systemic lupus erythematosus. Immunity 1(3):219-29 |
| abstractText | Susceptibility to glomerulonephritis (GN) and anti-dsDNA autoantibody production was analyzed in crosses with a newly developed systemic lupus erythematosus-susceptible inbred strain, NZM/Aeg2410. The mode of inheritance and the number and location of systemic lupus erythematosus-associated susceptibility loci were analyzed by interval mapping in a backcross with C57BL/6. Three chromosomal intervals containing strong recessive GN susceptibility alleles were identified on chromosomes 1, 4, and 7, each containing several potentially interesting candidate genes. Heterozygosity at H-2 was also found to correlate strongly with GN susceptibility, consistent with previous findings in the NZB/NZW parental strain model. Logistic regression analysis indicated that each of these susceptibility alleles independently accounted for a component of GN susceptibility, and that susceptibility was inherited as a threshold genetic liability in this model system. |
