| First Author | Ramiro AR | Year | 2004 |
| Journal | Cell | Volume | 118 |
| Issue | 4 | Pages | 431-8 |
| PubMed ID | 15315756 | Mgi Jnum | J:92464 |
| Mgi Id | MGI:3052876 | Doi | 10.1016/j.cell.2004.08.006 |
| Citation | Ramiro AR, et al. (2004) AID is required for c-myc/IgH chromosome translocations in vivo. Cell 118(4):431-8 |
| abstractText | Chromosome translocations between c-myc and immunoglobulin (Ig) are associated with Burkitt's lymphoma in humans and with pristane- and IL6-induced plasmacytomas in mice. These translocations frequently involve Ig switch regions, suggesting that they might be the result of aberrant Ig class switch recombination (CSR). However, a direct link between CSR and chromosome translocations has not been established. We have examined c-myc/IgH translocations in IL6 transgenic mice that are mutant for activation induced cytidine deaminase (AID), the enzyme that initiates CSR. Here we report that AID is essential for the c-myc/IgH chromosome translocations induced by IL6. |
