| First Author | Cattoretti G | Year | 2005 |
| Journal | Cancer Cell | Volume | 7 |
| Issue | 5 | Pages | 445-55 |
| PubMed ID | 15894265 | Mgi Jnum | J:98937 |
| Mgi Id | MGI:3580752 | Doi | 10.1016/j.ccr.2005.03.037 |
| Citation | Cattoretti G, et al. (2005) Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice. Cancer Cell 7(5):445-55 |
| abstractText | Diffuse large B cell lymphomas (DLBCL) derive from germinal center (GC) B cells and display chromosomal alterations deregulating the expression of BCL6, a transcriptional repressor required for GC formation. To investigate the role of BCL6 in DLBCL pathogenesis, we have engineered mice that express BCL6 constitutively in B cells by mimicking a chromosomal translocation found in human DLBCL. These mice display increased GC formation and perturbed post-GC differentiation characterized by a decreased number of post-isotype switch plasma cells. Subsequently, these mice develop a lymphoproliferative syndrome that culminates with the development of lymphomas displaying features typical of human DLBCL. These results define the oncogenic role of BCL6 in the pathogenesis of DLBCL and provide a faithful mouse model of this common disease. |
