| First Author | Pereira RA | Year | 2001 |
| Journal | J Immunol | Volume | 166 |
| Issue | 10 | Pages | 5869-73 |
| PubMed ID | 11342599 | Mgi Jnum | J:69352 |
| Mgi Id | MGI:1934483 | Doi | 10.4049/jimmunol.166.10.5869 |
| Citation | Pereira RA, et al. (2001) Cutting edge: a NK complex-linked locus governs acute versus latent herpes simplex virus infection of neurons. J Immunol 166(10):5869-73 |
| abstractText | Herpes simplex causes latent infections that periodically reactivate. Specific immunization attempts are failing to control herpes, prompting a fresh look at which host responses predominate. We report a NK complex-linked genetic locus, Rhs1, whose alleles influence the magnitude of experimental herpes simplex. Rhs1 provided rapid control of primary infection but caused a reciprocal increase in the number of latently infected neurons. Thus, in principle, establishment of latency is a consequence of efficient front line defense against herpesvirus infection. Based on conservation between human and mouse NK complexes, the data predict the presence of a human Rhs1 orthologue on chromosome 12p12-13. |
