| Primary Identifier | MGI:2156166 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Adam3 |
| Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A genomic fragment containing exon 3 was replaced with a neomycin selection cassette in opposite transcriptional orientation to the gene. RT-PCR analysis detected the presence of a trancript that spliced exon 2 to 4, but this mutation introduces a frameshift and premature stop codon. Western blots on testicular extracts confirmed the absence of the full length protein in homozygous mice. |
