| First Author | Fan X | Year | 2019 |
| Journal | Mol Carcinog | Volume | 58 |
| Issue | 12 | Pages | 2241-2253 |
| PubMed ID | 31512783 | Mgi Jnum | J:306130 |
| Mgi Id | MGI:6510211 | Doi | 10.1002/mc.23112 |
| Citation | Fan X, et al. (2019) A basal-enriched microRNA is required for prostate tumorigenesis in a Pten knockout mouse model. Mol Carcinog 58(12):2241-2253 |
| abstractText | MicroRNAs (miRNAs) play important roles in prostate cancer development. However, it remains unclear how individual miRNAs contribute to the initiation and progression of prostate cancer. Here we show that a basal layer-enriched miRNA is required for prostate tumorigenesis. We identify miR-205 as the most highly expressed miRNA and enriched in the basal cells of the prostate. Although miR-205 is not required for normal prostate development and homeostasis, genetic deletion of miR-205 in a Pten null tumor model significantly compromises tumor progression and does not promote metastasis. In Pten null basal cells, loss of miR-205 attenuates pAkt levels and promotes cellular senescence. Furthermore, although overexpression of miR-205 in prostate cancer cells with luminal phenotypes inhibits cell growth in both human and mouse, miR-205 has a minimal effect on the growth of a normal human prostate cell line. Taken together, we have provided genetic evidence for a requirement of miR-205 in the progression of Pten null-induced prostate cancer. |
