| First Author | Zheng W | Year | 2010 |
| Journal | EMBO Rep | Volume | 11 |
| Issue | 11 | Pages | 890-5 |
| PubMed ID | 20930845 | Mgi Jnum | J:165798 |
| Mgi Id | MGI:4838478 | Doi | 10.1038/embor.2010.144 |
| Citation | Zheng W, et al. (2010) Maternal phosphatidylinositol 3-kinase signalling is crucial for embryonic genome activation and preimplantation embryogenesis. EMBO Rep 11(11):890-5 |
| abstractText | Maternal effect factors derived from oocytes are important for sustaining early embryonic development before the major wave of embryonic genome activation (EGA). In this study, we report a two-cell-stage arrest of embryos lacking maternal 3-phosphoinositide-dependent protein kinase 1 as a result of suppressed EGA. Concurrent deletion of maternal Pten completely rescued the suppressed EGA and embryonic progression through restored AKT signalling, which fully restored the fertility of double-mutant females. Our study identifies maternal phosphatidylinositol 3-kinase signalling as a new maternal effect factor that regulates EGA and preimplantation embryogenesis in mice. |
