| First Author | Jorgensen TN | Year | 2007 |
| Journal | J Immunol | Volume | 179 |
| Issue | 6 | Pages | 3417-24 |
| PubMed ID | 17785775 | Mgi Jnum | J:152058 |
| Mgi Id | MGI:4355820 | Doi | 10.4049/jimmunol.179.6.3417 |
| Citation | Jorgensen TN, et al. (2007) Bim and Bcl-2 mutually affect the expression of the other in T cells. J Immunol 179(6):3417-24 |
| abstractText | The life and death of T cells is controlled to a large extent by the relative amounts of Bcl-2-related proteins they contain. The antiapoptotic protein Bcl-2 and the proapoptotic protein Bim are particularly important in this process with the amount of Bcl-2 per cell dropping by about one-half when T cells prepare to die. In this study we show that Bcl-2 and Bim each control the expression of the other. Absence of Bim leads to a drop in the amount of intracellular Bcl-2 protein, while having no effect on the amounts of mRNA for Bcl-2. Conversely, high amounts of Bcl-2 per cell allow high amounts of Bim, although in this case the effect involves increases in Bim mRNA. These mutual effects occur even if Bcl-2 is induced acutely. Thus these two proteins control the expression of the other, at either the protein or mRNA level. |
