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Publication : The transcriptional landscape of αβ T cell differentiation.

First Author	Mingueneau M	Year	2013
Journal	Nat Immunol	Volume	14
Issue	6	Pages	619-32
PubMed ID	23644507	Mgi Jnum	J:259369
Mgi Id	MGI:6141362	Doi	10.1038/ni.2590
Citation	Mingueneau M, et al. (2013) The transcriptional landscape of alphabeta T cell differentiation. Nat Immunol 14(6):619-32

abstractText

The differentiation of alphabetaT cells from thymic precursors is a complex process essential for adaptive immunity. Here we exploited the breadth of expression data sets from the Immunological Genome Project to analyze how the differentiation of thymic precursors gives rise to mature T cell transcriptomes. We found that early T cell commitment was driven by unexpectedly gradual changes. In contrast, transit through the CD4(+)CD8(+) stage involved a global shutdown of housekeeping genes that is rare among cells of the immune system and correlated tightly with expression of the transcription factor c-Myc. Selection driven by major histocompatibility complex (MHC) molecules promoted a large-scale transcriptional reactivation. We identified distinct signatures that marked cells destined for positive selection versus apoptotic deletion. Differences in the expression of unexpectedly few genes accompanied commitment to the CD4(+) or CD8(+) lineage, a similarity that carried through to peripheral T cells and their activation, demonstrated by mass cytometry phosphoproteomics. The transcripts newly identified as encoding candidate mediators of key transitions help define the ''known unknowns'' of thymocyte differentiation.

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Publication : The transcriptional landscape of αβ T cell differentiation.

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