| First Author | D'Souza WN | Year | 2008 |
| Journal | J Immunol | Volume | 181 |
| Issue | 11 | Pages | 7617-29 |
| PubMed ID | 19017950 | Mgi Jnum | J:142200 |
| Mgi Id | MGI:3820725 | Doi | 10.4049/jimmunol.181.11.7617 |
| Citation | D'Souza WN, et al. (2008) The Erk2 MAPK regulates CD8 T cell proliferation and survival. J Immunol 181(11):7617-29 |
| abstractText | The magnitude of T cell responses is determined by proliferation and survival decisions made by the responding cells. We now demonstrate that the Erk MAPK pathway plays a critical role in these cell fate decisions within CD8 T cells. While Erk1 is dispensable for all aspects of CD8 T cell activation, Erk2 is required for the proliferation of CD8 T cells activated in the absence of costimulation. Surprisingly, Erk2 is not required for proliferation following the addition of a costimulatory signal in vitro, or upon viral infection in vivo, but regulates the size of the responding population by enhancing cell survival. An important component of this Erk2-derived signal is the transcriptional regulation of Bcl-2 family members Bcl-x(L) and Bim, and impaired Erk2-deficient CD8 T cell survival can be rescued by genetic ablation of Bim. These studies ascribe multifaceted functions specific to Erk2 in CD8 T cell activation, proliferation, and survival. |
