| First Author | Szymczak-Workman AL | Year | 2011 |
| Journal | J Immunol | Volume | 187 |
| Issue | 9 | Pages | 4416-20 |
| PubMed ID | 21949016 | Mgi Jnum | J:179446 |
| Mgi Id | MGI:5302440 | Doi | 10.4049/jimmunol.1100548 |
| Citation | Szymczak-Workman AL, et al. (2011) Cutting edge: Regulatory T cells do not mediate suppression via programmed cell death pathways. J Immunol 187(9):4416-20 |
| abstractText | Regulatory T cells (Tregs) play a critical role in the immune system to regulate peripheral tolerance and prevent autoimmunity. However, the relative importance of different mechanisms of Treg function remains obscure. In this article, we reveal a limited role for programmed cell death pathways in mediating Treg suppression of conventional T cells. We show that Tregs are able to suppress the proliferation of conventional T cells that are resistant to apoptosis (Bim(-/-), Bim(-/-)Puma(-/-), Bcl-2 transgenic) or receptor-interacting serine-threonine kinase-dependent necrosis (also referred to as regulated necrosis or necroptosis) (Ripk3(-/-)) in several in vitro and in vivo assays. These data suggest that programmed cell death pathways, such as apoptosis and receptor-interacting serine-threonine kinase-dependent necrosis, are not required for Treg-mediated suppression. |
