| First Author | Nguyen HV | Year | 2023 |
| Journal | Cell Death Differ | Volume | 30 |
| Issue | 4 | Pages | 1018-1032 |
| PubMed ID | 36755068 | Mgi Jnum | J:334557 |
| Mgi Id | MGI:7461001 | Doi | 10.1038/s41418-023-01119-y |
| Citation | Nguyen HV, et al. (2023) MNT suppresses T cell apoptosis via BIM and is critical for T lymphomagenesis. Cell Death Differ 30(4):1018-1032 |
| abstractText | The importance of c-MYC in regulating lymphopoiesis and promoting lymphomagenesis is well-established. Far less appreciated is the vital supporting role of MYC's relative MNT. Using Rag1Cre-mediated Mnt deletion in lymphoid progenitor cells, we show here that, during normal T cell development, MNT loss enhances apoptosis, at least in part by elevating expression of the pro-apoptotic BH3-only protein BIM. Moreover, using T lymphoma-prone VavP-MYC transgenic mice, we show that Mnt deletion reduces the pool of pre-malignant MYC-driven T lymphoid cells and abrogates thymic T lymphomagenesis. In addition, we establish that Mnt deletion prevents T lymphoma development in gamma-irradiated mice, most likely by enhancing apoptosis of T lymphoid cells repopulating the depleted thymus. Taken together with our recent demonstration that MNT is vital for the survival of MYC-driven pre-malignant and malignant B lymphoid cells, these results suggest that MNT represents an important new drug target for both T and B lymphoid malignancies. |
