| First Author | Newman R | Year | 2017 |
| Journal | Nat Immunol | Volume | 18 |
| Issue | 6 | Pages | 683-693 |
| PubMed ID | 28394372 | Mgi Jnum | J:259588 |
| Mgi Id | MGI:6141860 | Doi | 10.1038/ni.3724 |
| Citation | Newman R, et al. (2017) Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1. Nat Immunol 18(6):683-693 |
| abstractText | RNA-binding proteins of the ZFP36 family are best known for inhibiting the expression of cytokines through binding to AU-rich elements in the 3'' untranslated region and promoting mRNA decay. Here we identified an indispensable role for ZFP36L1 as the regulator of a post-transcriptional hub that determined the identity of marginal-zone B cells by promoting their proper localization and survival. ZFP36L1 controlled a gene-expression program related to signaling, cell adhesion and locomotion; it achieved this in part by limiting expression of the transcription factors KLF2 and IRF8, which are known to enforce the follicular B cell phenotype. These mechanisms emphasize the importance of integrating transcriptional and post-transcriptional processes by RNA-binding proteins for maintaining cellular identity among closely related cell types. |
