| First Author | Arandjelovic S | Year | 2010 |
| Journal | J Leukoc Biol | Volume | 88 |
| Issue | 4 | Pages | 737-45 |
| PubMed ID | 20643816 | Mgi Jnum | J:165609 |
| Mgi Id | MGI:4837810 | Doi | 10.1189/jlb.0310131 |
| Citation | Arandjelovic S, et al. (2010) Mast cell function is not altered by Coronin-1A deficiency. J Leukoc Biol 88(4):737-45 |
| abstractText | Coronin-1A is a WD repeat protein family member, highly expressed in all hematopoietic lineages, and acts as a regulator of F-actin dynamics and Ca2+ signaling. In Coro1a(Lmb3) mice results in inactivation of the protein and leads to disease resistance in a model of lupus erythematosus. In Coro1a(-/-) and Coro1a(Lmb3) mice, peripheral T cells exhibit impairments in survival, migration, activation, and Ca2+ flux. In this study, we show that in vitro-differentiated mast cells from Coro1a(Lmb3) mice are viable, developed normally, and are fully functional in assays of degranulation, cytokine secretion, and chemotactic migration, despite increased F-actin levels. In Coro1a(Lmb3) mast cells, Ca2+ flux in response to physiological FcepsilonRI stimulation is unaffected. Finally, Coro1a(Lmb3) mice showed similar in vivo mast cell responses as the WT mice. Coronin-1B and Coronin-1C expression levels were not increased in Coro1a(Lmb3) mast cells but were higher in mast cells than in CD4 T cells or B cells in WT mice. We conclude that Coronin-1A activity is not required for mast cell function. |
