| First Author | Hermans MH | Year | 1998 |
| Journal | Blood | Volume | 92 |
| Issue | 1 | Pages | 32-9 |
| PubMed ID | 9639496 | Mgi Jnum | J:48503 |
| Mgi Id | MGI:1270073 | Doi | 10.1182/blood.v92.1.32.413k42_32_39 |
| Citation | Hermans MH, et al. (1998) Perturbed granulopoiesis in mice with a targeted mutation in the granulocyte colony-stimulating factor receptor gene associated with severe chronic neutropenia. Blood 92(1):32-9 |
| abstractText | Mutations in the granulocyte colony-stimulating factor (G-CSF) receptor gene are found in a number of patients with severe chronic neutropenia predisposed to acute myeloid leukemia. These mutations result in the absence of the C-terminal domain of the G-CSF-R, a region which has been implicated in differentiation signaling. We generated mice with an equivalent mutation (gcsfr-triangle Delta715) by homologous and Cre-mediated recombination in embryonic stem cells. Both wt/triangle Delta715 and triangle Delta715/triangle Delta715 mice have significantly reduced numbers of blood neutrophils compared with their wt/wt littermates. However, under continuous G-CSF administration mutant mice develop peripheral neutrophil counts that significantly exceed those of wild-type littermates. These findings indicate that depending on G-CSF levels in mice, the triangle Delta715 mutation can contribute both to neutropenia and to neutrophilia. |
