| First Author | Semerad CL | Year | 2002 |
| Journal | Immunity | Volume | 17 |
| Issue | 4 | Pages | 413-23 |
| PubMed ID | 12387736 | Mgi Jnum | J:79567 |
| Mgi Id | MGI:2388502 | Doi | 10.1016/s1074-7613(02)00424-7 |
| Citation | Semerad CL, et al. (2002) G-CSF Is an Essential Regulator of Neutrophil Trafficking from the Bone Marrow to the Blood. Immunity 17(4):413 |
| abstractText | Neutrophils are released from the bone marrow in a regulated fashion to maintain homeostatic levels in the blood and to respond to physiological stresses, including infection. We show that under basal conditions granulocyte colony-stimulating factor (G-CSF) is an essential regulator of neutrophil release from the bone marrow. Nonredundant signals generated by the membrane-proximal 87 amino acids of the G-CSF receptor (G-CSFR) are sufficient to mediate this response. Surprisingly, G-CSFR expression on neutrophils is neither necessary nor sufficient for their mobilization from the bone marrow, suggesting that G-CSF induces neutrophil mobilization indirectly through the generation of trans-acting signals. Evidence is provided suggesting that downregulation of stromal cell-derived factor 1 expression in the bone marrow may represent such a signal. |
